A nation-wide study of U.S. adults published in the Annals of Medicine found that markers of exposure to phthalate plasticizers were associated with changes in kidney function.
In short:
Due to regulatory restrictions, DEHP use is declining, but the use of replacement plasticizers is increasing. This study measured markers of exposure to both types, DEHP and two of its replacements, DEHTP and DiNP. It found that:
- Markers of DEHP were associated with lower kidney function.
- Markers of the replacement chemical DEHTP were associated with higher kidney function, a possible sign of early kidney disease.
- There were also interactions among some of the chemicals.
Key quote:
“Our findings link urinary plasticizer metabolites to reduced renal function, suggesting that chronic exposure to these chemicals may elevate the risk of chronic kidney disease and other renal disorders.”
Why this matters:
The authors point out that people are exposed to phthalate plasticizers via a wide array of products, from building materials such as vinyl flooring; to consumer goods such as plastics, toys, and synthetic fabrics; to personal care items such as soaps, shampoos, and nail polish; to medical supplies such as blood storage bags and plastic tubing. Laboratory studies support the kidney toxicity of some of these plasticizers (DEHP and DiNP), although studies on DEHTP and the kidney are limited. They call for more research on kidney impairment in relation to plasticizer exposure.
Related EHN coverage:
- Op-ed: Strengthening microplastic regulation to protect our kidneys
- Phthalates detected in 11 popular brands of essential oils
- Plastic chemicals are more numerable and less regulated than previously thought: Report
More resources:
- Environmental Working Group: What are phthalates?
- Mamavation: Testing results for phthalates in consumer products
