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BPA replacement linked to increased cardiovascular disease

BPA replacement linked to increased cardiovascular disease

“It's not surprising that chemicals that are structurally similar to BPA are going to have similar effects on human populations.”

3 min read

Bisphenol-S (BPS), a replacement chemical for bisphenol-A (BPA), may increase the risk of cardiovascular disease in the U.S. population, according to a new study published earlier this month in Environmental Sciences Europe.


A near-ubiquitous ingredient in plastic products, BPA is increasingly replaced by cousin chemicals — such as Bisphenol F (BPF) or BPS — due to mounting health concerns. However, scientists are now uncovering that these replacement chemicals may be as harmful as BPA.

The study tapped into data from the National Health and Nutrition Examination Survey between 2013 and 2016 conducted by the Centers for Disease Control and Prevention (CDC). After examining more than 1,200 participants with available bisphenol and cardiovascular disease data, the scientists derived a significant association between urinary BPS and an increased risk of cardiovascular disease, especially in people aged 50–80 years. Specifically, the researchers found a positive correlation between urinary BPS and coronary heart disease risk.

“Although BPA, BPS, and BPF share similar chemical properties, BPS and BPF are not safe alternatives for BPA,” the study authors concluded in the paper.

Laura Vandenberg, an endocrinologist at University of Massachusetts, Amherst who was not involved in this study, told EHN that the finding in this study is “pretty consistent” with previous scientific evidence. “It's not surprising that chemicals that are structurally similar to BPA are going to have similar effects on human populations,” said Vandenberg, who spent almost the last two decades studying endocrine disruptors, including BPA and its replacements.

Replacements for BPA

A key ingredient in polycarbonate, a hard, clear plastic, and epoxy resins, which act as a protective lining in food and beverage packaging, BPA can be found in all corners of our lives — shatterproof windows, eyeglasses, water bottles, metal food cans, water pipes, and medical supplies, to name a few.

Although BPA does not stick around in our body, it is still a great health concern “because we're constantly being exposed to it,” Vandenberg said. By mimicking estrogens, BPA molecules can forestall estrogen receptors, triggering a plethora of molecular pathways down to adverse health outcomes. Previous studies have linked BPA to heart diseases, obesity, diabetes, hypertension, brain and reproductive system damages, and children's behavior problems.

By design, most replacement bisphenols bear similar chemical structures as BPA to achieve parallel characteristics in products. While a BPA molecule looks similar to a batman symbol, the molecules of replacement bisphenols “look like the batman symbol with antenna,” said Vandenberg. Therefore, scientists are also finding comparable biological effects from these BPA replacements on our bodies.

“The bisphenols we've looked at have similar effects on the hearts,” Glen Pyle, a biomedical professor at University of Guelph in Canada who was not involved in the study, told EHN. Pyle’s team investigates the molecular cardiology of BPA and its replacements in animal models. His research demonstrated that, with subtle mechanistic differences, both BPS and BPA can depress the ability of the heart to contract by disrupting the calcium flow inside the cell, sabotaging the heart’s force.

BPA and bisphenol regulation

Despite sweeping concerns, the U.S. Food and Drug Administration still considers BPA “safe at the current levels occurring in foods.” As a result, BPA and its analogous replacements are still free-floating in the U.S., except for baby bottles, sippy cups, and infant formula packaging.

Meanwhile, European regulators recently recommended slashing the recommended daily dose of BPA by 100,000, which would ensure the chemical cannot be used in any food contact products. A group of U.S. health professionals recently petitioned the FDA to revisit BPA’s safety in light of the European findings and recommendations.

“The FDA really has ignored a lot of data on BPA,” said Vandenberg. “I think that it's time for that to change.” In addition to BPA, scientists are also racing to keep tabs on the health impact of BPA replacements, as they continue to emerge. “The metaphor of ‘Whack a Mole’ is really a very common one,” said Vandenberg. “It is frustrating.”

As for the BPA-free labels on products, Pyle said they mean “not much” for the consumers as they often contain BPA-replacements. “I think one of the simplest things we can do [to avoid bisphenols] is to reduce our use of plastics when it's not necessary,” he said.

Banner photo credit: Muhammad Syahid Abdillah/Unsplash

About the author(s):

Huanjia Zhang

Huanjia Zhang is a Science and Healthcare Reporter at GenomeWeb. He holds an M.A. in Science, Health, and Environmental Reporting from NYU.

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